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This is a first-in-human, Phase 1/2, open-label, study designed to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and prelimi...
Phase 1, Phase 2
Huntersville, North Carolina, United States of America and 5 other locations
The study will compare the efficacy and safety of pembrolizumab plus trastuzumab in combination with standard of care (SOC) chemotherapy versus trast...
Phase 3
Charlotte, North Carolina, United States and 191 other locations
Zolbetuximab is being studied as a treatment for people with pancreatic cancer. Most people with pancreatic cancer have a protein called Claudin 18.2...
Phase 2
Charlotte, North Carolina, United States and 135 other locations
Phase I Study of NT-175, an autologous T cell therapy product genetically engineered to express an HLA-A\*02:01-restricted T cell receptor (TCR), tar...
Phase 1
Charlotte, North Carolina, United States and 14 other locations
This is an open-label, Phase 1/2 study to determine the safety, tolerability, and efficacy of APL-5125 for the treatment of selected locally advanced...
Phase 1, Phase 2
Huntersville, North Carolina, United States of America and 8 other locations
a dose expansion phase to confirm the dose and combination with bevacizumab. Approximately 500 adult participants with NSCLC, gastroesophageal adenocarcinoma...
Phase 1
Huntersville, North Carolina, United States of America and 84 other locations
adenocarcinoma. Enrollment in the expansion cohorts is limited to the following tumor types: endometrial, SCCHN, CRC, and a basket cohort i...
Phase 1
Huntersville, North Carolina, United States of America and 10 other locations
This is an open-label, dose-escalation and dose-expansion study to determine the safety, tolerability, PK, pharmacodynamics, and preliminary efficacy...
Phase 1
Huntersville, North Carolina, United States and 42 other locations
This study is to evaluate the safety and tolerability of RMC-9805 as monotherapy and in combination with RMC-6236 in adults with KRAS G12D-mutant sol...
Phase 1
Huntersville, North Carolina, United States of America and 16 other locations
The main objective of this study is to compare efficacy of bemarituzumab combined with oxaliplatin, leucovorin, and 5-fluorouracil (5-FU) (mFOLFOX6)...
Phase 3
Charlotte, North Carolina, United States and 300 other locations
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