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participants to treat locally advanced unresectable or metastatic gastric, gastroesophageal junction, or esophageal adenocarcinoma (mGEA).T...
Phase 2
Durham, North Carolina, United States and 46 other locations
The purpose of this study is to combine standard radiation therapy with drugs that encourages the body's immune system against cancer cells and simul...
Phase 2
Chapel Hill, North Carolina, United States and 4 other locations
The purpose of this study is to evaluate the safety and efficacy of a novel RAS(ON) inhibitor compared to standard(s) of care (SOC) treatment.
Phase 3
Durham, North Carolina, United States and 59 other locations
with chemotherapy in participants with previously untreated advanced or metastatic gastric, gastroesophageal junction, or esophageal adenocarcinoma...
Phase 2, Phase 3
Chapel Hill, North Carolina, United States and 158 other locations
T-cells in Subjects with Unresectable, Locally Advanced, or Metastatic Gastric, Gastroesophageal Junction (GEJ), Esophageal, or Pancreatic Adenocarcinoma...
Phase 1
Durham, North Carolina, United States and 8 other locations
first-line treatment of participants with locally advanced unresectable or metastatic gastric, gastroesophageal junction (GEJ), and esophageal adenocarcinoma...
Phase 3
Durham, North Carolina, United States and 212 other locations
Zolbetuximab is being studied in people with cancer in and around the stomach or where the food pipe (esophagus) joins the stomach, called gastroesop...
Phase 3
Durham, North Carolina, United States and 186 other locations
Claudin 18.2 protein, or CLDN18.2 is a protein found on cells in the digestive system. It is also found on some tumors. Researchers are looking at wa...
Phase 1
Durham, North Carolina, United States and 43 other locations
This is an open label Phase 2 study to evaluate the efficacy and safety of ACR-368 as monotherapy or with ultra-low dose gemcitabine (ULDG) sensitiza...
Phase 2
Chapel Hill, North Carolina, United States and 89 other locations
Some people with pancreatic ductal cancer (PDAC) have a protein called Claudin 18.2 (CLDN18.2) in their tumor. ASP2138 is thought to work by binding...
Phase 1
Durham, North Carolina, United States and 2 other locations
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