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Find clinical trials for Glioblastoma (GBM) in London, England

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Related conditions:

Glioblastoma
Brain Cancer
Glioma
Astrocytoma
Cancer
Recurrence
Gliosarcoma

Glioblastoma (GBM) trials near London, England, GBR:

5G-EMERALD: Amivantamab in Malignant Brain Tumours

The purpose of this clinical trial is to evaluate the safety and tolerability of amivantamab and to determine the preliminary antitumour activity of...

Enrolling
Glioblastoma Multiform (Grade IV Astrocytoma)
Glioblastoma Multiforme (GBM)
Drug: Amivantamab

Phase 1

Institute of Cancer Research, United Kingdom

Sutton, United Kingdom and 1 other location

a treatment in any biomarker arm has met the "GO" decision (≥3 successes/12 patients) for relapsed GBM in Phase 1b, that arm can progress t...

Enrolling
Glioblastoma Multiform (Grade IV Astrocytoma)
Glioblastoma Multiforme (GBM)
Drug: Avutometinib
Drug: Defactinib

Phase 1, Phase 2

Institute of Cancer Research, United Kingdom

Sutton, United Kingdom and 2 other locations

placebo-controlled, randomised trial to compare the cannabinoid Nabiximols with placebo in patients with recurrent MGMT methylated glioblastoma...

Enrolling
Glioblastoma
Brain Tumor, Recurrent
Drug: Nabiximols-matched placebo
Drug: Nabiximols

Phase 2

University of Birmingham

London, United Kingdom and 21 other locations

Optune® together with maintenance TMZ and placebo in newly diagnosed Glioblastoma (GBM) patients. The primary objective of the stud...

Enrolling
Glioblastoma
Drug: Temozolomide
Drug: Placebo

Phase 3

NovoCure
NovoCure

Sutton, United Kingdom and 71 other locations

The purpose of this first-in-human (FIH) study of \[177Lu\]-NeoB is to characterize the safety, tolerability, pharmacokinetics (PK) as well as the di...

Active, not recruiting
Neoplasms
Drug: [68Ga]-NeoB
Drug: LCZ696

Phase 1, Phase 2

Advanced Accelerator Applications

Cambridge, United Kingdom and 10 other locations

To test the effectiveness and safety of Optune® given concomitantly with radiation therapy (RT) and temozolomide (TMZ) in newly diagnosed GBM...

Active, not recruiting
Glioblastoma Multiforme
Device: Optune®
NovoCure
NovoCure

London, United Kingdom and 132 other locations

(TMZ) in adult participants with newly-diagnosed, MGMT unmethylated glioblastoma multiforme (GBM). The main questions it aims to an...

Enrolling
Glioblastoma
GBM
Drug: Niraparib
Drug: Temozolomide

Phase 3

Ivy Brain Tumor Center

London, United Kingdom and 85 other locations

This is an open-label, two-part, phase 1-2 dose-finding study designed to determine the safety, tolerability, PK, PD, and proof-of-concept efficacy o...

Active, not recruiting
Glioblastoma
Glioblastoma Multiforme
Drug: ST101
Drug: Temozolomide

Phase 1, Phase 2

Sapience Therapeutics

London, United Kingdom and 10 other locations

This study will test an investigational drug called AZD1390 in combination with radiation therapy for the treatment of brain tumors. This is the firs...

Enrolling
Recurrent Glioblastoma Multiforme
Primary Glioblastoma Multiforme
Drug: AZD1390
Radiation: Radiation Therapy

Phase 1

AstraZeneca
AstraZeneca

London, United Kingdom and 11 other locations

This is a single centre, proof-of-concept phase I trial of atezolizumab in combination with ipatasertib. There are two parts to this study, the dose...

Active, not recruiting
Glioblastoma Multiforme
Solid Tumor
Drug: ipatasertib
Drug: Atezolizumab

Phase 1, Phase 2

Institute of Cancer Research, United Kingdom

Sutton, Surrey, United Kingdom

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