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Find clinical trials for Melanoma in Philadelphia, PA

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Melanoma trials near Philadelphia, PA, USA:

(Neo)Adjuvant IDE196 (Darovasertib) in Patients With Localized Ocular Melanoma

Neoadjuvant/adjuvant IDE196 (darovasertib) in patients with primary uveal melanoma...

Active, not recruiting
Uveal Melanoma
Drug: Darovasertib

Phase 2

Ideaya Biosciences

Philadelphia, Pennsylvania, United States and 17 other locations

This is a Phase 3, randomized, multi-center, open-label study of neoadjuvant darovasertib in subjects with primary non-metastatic uveal melanoma...

Enrolling
Uveal Melanoma
Procedure: Primary Local Therapy
Drug: Darovasertib

Phase 3

Ideaya Biosciences

Philadelphia, Pennsylvania, United States and 86 other locations

manner the recurrence-free survival (RFS) of Stage IIIB/C/D melanoma patients with respect to the standard of care (surgery and adjuvant the...

Enrolling
Melanoma Stage IIID
Melanoma Stage IIIC
Drug: Adjuvant therapy
Procedure: Surgery

Phase 3

Philogen
Philogen

Philadelphia, Pennsylvania, United States and 36 other locations

The goal of this clinical trial is to understand if a new drug called LNS8801 can safely treat patients with melanoma. The primary question ...

Enrolling
Melanoma Stage IIIB-IV
Melanoma (Skin Cancer)
Biological: Immunotherapy (ipilimumab and nivolumab)
Biological: Immunotherapy (Pembrolizumab)

Phase 2, Phase 3

Linnaeus Therapeutics

Philadelphia, Pennsylvania, United States and 6 other locations

alone in participants with untreated, unresectable or metastatic melanoma. Participants randomized to the pembrolizumab monotherapy arm who ...

Enrolling
Melanoma
Unresectable Melanoma
Biological: Pembrolizumab with Optional Crossover Period
Biological: Lifileucel plus Pembrolizumab

Phase 3

Iovance Biotherapeutics

Camden, New Jersey, United States of America and 71 other locations

therapy per local standard of care \[SoC\], best supportive care \[BSC\] on protocol survivor follow up) in patients with advanced non-ocular melanoma...

Enrolling
Advanced Melanoma
Drug: Tebentafusp with Pembrolizumab
Drug: Tebentafusp

Phase 3

Immunocore
Immunocore

Philadelphia, Pennsylvania, United States and 81 other locations

of using hydroxychloroquine (HCQ) in combination with nivolumab and ipilimumab or with nivolumab alone in subjects with advanced/metastatic melanoma...

Enrolling
Melanoma
Drug: Nivolumab
Drug: Hydroxychloroquine

Phase 1, Phase 2

Ravi Amaravadi, MD

Philadelphia, Pennsylvania, United States

cell death protein-1 (PD-1) inhibitor, in patients with metastatic melanomas or advanced solid tumors. Our hypothesis is that restoration of...

Active, not recruiting
Mucosal Melanoma
Melanoma
Drug: Phase 1b: APG-115+pembrolizumab

Phase 1, Phase 2

Ascentage Pharma Group
Ascentage Pharma Group

Philadelphia, Pennsylvania, United States and 20 other locations

The study is focused on patients with a type of skin cancer known as melanoma. The aim of the study is to see how safe and effective the com...

Enrolling
Melanoma
Drug: fianlimab
Drug: cemiplimab

Phase 3

Regeneron Pharmaceuticals
Regeneron Pharmaceuticals

Philadelphia, Pennsylvania, United States of America and 107 other locations

efficacy of belzupacap sarotalocan (bel-sar) compared to sham control in patients with primary indeterminate lesions (IL) or small choroidal melanoma...

Enrolling
Ocular Melanoma
Choroidal Melanoma
Device: Suprachoroidal Microinjector
Drug: Bel-sar

Phase 3

Aura Biosciences
Aura Biosciences

Philadelphia, Pennsylvania, United States and 72 other locations

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