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Find clinical trials for Melanoma in Pittsburgh, PA

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Melanoma trials near Pittsburgh, PA, USA:

A Trial of Pembrolizumab and Metformin Versus Pembrolizumab Alone in Advanced Melanoma

The purpose of this study is to evaluate the effectiveness and safety of the combination of Pembrolizumab (KEYTRUDA®) and the investigational drug, M...

Enrolling
Advanced Melanoma
Drug: Metformin
Drug: Pembrolizumab Injection [Keytruda]

Phase 1

Yana Najjar

Pittsburgh, Pennsylvania, United States

ATLAS-IT-05 is an open-label, single-arm study in patients with advanced melanoma accessible for injections (cutaneous, subcutaneous, lymph ...

Active, not recruiting
Advanced Melanoma
Combination Product: LTX-315 in combination with pembrolizumab

Phase 2

Lytix Biopharma

Pittsburgh, Pennsylvania, United States and 9 other locations

alone in participants with untreated, unresectable or metastatic melanoma. Participants randomized to the pembrolizumab monotherapy arm who ...

Enrolling
Melanoma
Unresectable Melanoma
Biological: Pembrolizumab with Optional Crossover Period
Biological: Lifileucel plus Pembrolizumab

Phase 3

Iovance Biotherapeutics

Pittsburgh, Pennsylvania, United States and 70 other locations

therapy per local standard of care \[SoC\], best supportive care \[BSC\] on protocol survivor follow up) in patients with advanced non-ocular melanoma...

Enrolling
Advanced Melanoma
Drug: Tebentafusp with Pembrolizumab
Drug: Tebentafusp

Phase 3

Immunocore
Immunocore

Pittsburgh, Pennsylvania, United States and 65 other locations

The study is focused on patients with a type of skin cancer known as melanoma. The aim of the study is to see how safe and effective the com...

Enrolling
Melanoma
Drug: fianlimab
Drug: cemiplimab

Phase 3

Regeneron Pharmaceuticals
Regeneron Pharmaceuticals

Pittsburgh, Pennsylvania, United States and 75 other locations

sub-type 1 receptor (MC1R) is being evaluated as a monotherapy and in combination with Nivolumab in subjects with unresectable and metastatic melanoma...

Enrolling
Mucosal Melanoma
Melanoma Stage IV
Drug: Nivolumab
Drug: [212Pb]VMT01

Phase 1, Phase 2

Perspective Therapeutics

Pittsburgh, Pennsylvania, United States and 10 other locations

This early-phase study will examine Vusolimogene Oderparepvec, a genetically modified oncolytic viral strain of the herpes simplex type 1 (HSV-1) vir...

Enrolling
Melanoma
Biological: Vusolimogene oderparepvec (RP1)

Early Phase 1

Yana Najjar

Pittsburgh, Pennsylvania, United States

This is Phase II trial of nivolumab plus axitinib for patients with unresectable stage III or IV melanoma who have progressed on prior anti-...

Active, not recruiting
Advanced Melanoma
Unresectable Melanoma
Drug: Axitinib
Drug: Nivolumab

Phase 2

Yana Najjar

Pittsburgh, Pennsylvania, United States

To evaluate the overall survival of HLA-A\*0201 positive adult patients with previously untreated advanced UM receiving IMCgp100 compared to Investig...

Active, not recruiting
Uveal Melanoma
Biological: IMCgp100
Biological: Pembrolizumab

Phase 2

Immunocore
Immunocore

Pittsburgh, Pennsylvania, United States and 56 other locations

antigen (HLA)-A\*02:01 negative participants with metastatic uveal melanoma (MUM) who will be randomized to receive either IDE196 + crizotin...

Enrolling
Metastatic Uveal Melanoma
Drug: IDE196
Drug: Nivolumab

Phase 2, Phase 3

Ideaya Biosciences

Pittsburg, Pennsylvania, United States and 66 other locations

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