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The primary objective of this study is to characterize the safety and tolerability of loncastuximab tesirine in combination with polatuzumab vedotin,...
Phase 1
Pittsburgh, Pennsylvania, United States and 41 other locations
a bifunctional cereblon-dependent ligand-directed degrader of B-cell lymphoma 6 (BCL6), as a single agent and in combination with anti-lymphoma...
Phase 1, Phase 2
Pittsburgh, Pennsylvania, United States and 34 other locations
of adult participants with relapsed or refractory (r/r) B-Cell non-Hodgkin lymphoma (B-NHL) or frontline high-risk diffuse...
Phase 1, Phase 2
Pittsburgh, Pennsylvania, United States and 30 other locations
pharmacokinetic, pharmacodynamic, and clinical activity of AZD0486, a CD19 x CD3 T-cell engaging bispecific antibody, in subjects with B-cell non...
Phase 1
Pittsburgh, Pennsylvania, United States and 28 other locations
chimeric antigen receptor (CAR) targeting cluster of differentiation (CD)19 and CD20 in participants with aggressive large B-cell lymphoma....
Phase 1, Phase 2
Pittsburgh, Pennsylvania, United States and 25 other locations
with polatuzumab vedotin in participants with diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and mantle cell lymphoma...
Phase 1, Phase 2
Pittsburgh, Pennsylvania, United States and 28 other locations
This study evaluates a fenretinide phospholipid suspension for the treatment of T-cell non-Hodgkin's lymphoma (NHL)....
Phase 1
Pittsburgh, Pennsylvania, United States and 9 other locations
This is a Phase I/II, multicenter, open-label, dose-escalation study designed to evaluate the efficacy, safety, tolerability and pharmacokinetics (PK...
Phase 1, Phase 2
Pittsburgh, Pennsylvania, United States and 37 other locations
monotherapy in adult participants with relapsed/refractory B-cell non-Hodgkin lymphoma (NHL) who have received at least tw...
Phase 2
Pittsburgh, Pennsylvania, United States and 92 other locations
CD19/CD20 CAR T-cell therapy, with investigator's choice of CD19 CAR T-cell therapy in patients with relapsed or refractory large B-cell lymphoma...
Phase 3
Pittsburgh, Pennsylvania, United States and 39 other locations
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