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compared to just chemotherapy alone in participants with metastatic pancreatic cancer. One group of participants will only receive ...
Phase 2
Cincinnati, Ohio, United States and 35 other locations
The purpose of this study is to evaluate the safety and efficacy of a novel RAS(ON) inhibitor compared to standard(s) of care (SOC) treatment.
Phase 3
Cincinnati, Ohio, United States and 57 other locations
is to evaluate the safety and tolerability of RMC-9805 as monotherapy and in combination with RMC-6236 in adults with KRAS G12D-mutant solid tumors...
Phase 1
Cincinnati, Ohio, United States and 16 other locations
Evaluate the safety and tolerability of RMC-6236 in adults with specific RAS mutant advanced solid tumors....
Phase 1
Cincinnati, Ohio, United States and 15 other locations
The purpose of this platform study is to evaluate the safety, tolerability, pharmacokinetics (PK), and preliminary antitumor activity of novel RAS(ON...
Phase 1, Phase 2
Cincinnati, Ohio, United States and 23 other locations
anti-CTLA4 IgG1 monoclonal antibody, as single agent and in combination with pembrolizumab in participants with advanced or metastatic solid tumors...
Phase 1, Phase 2
Cincinnati, Ohio, United States and 36 other locations
imaging time window of 64Cu-LNTH-1363S, and to compare its imaging biodistribution with FAP expression by IHC in patients with sarcomas or GIT cancers...
Phase 1, Phase 2
Cincinnati, Ohio, United States and 4 other locations
evaluate the safety, tolerability, drug levels, molecular effects, and clinical activity of MRTX849 (adagrasib) in patients with advanced solid tumors...
Phase 1, Phase 2
Cincinnati, Ohio, United States and 233 other locations
of large intestine) or rectum grow out of control.Pancreatic ductal adenocarcinoma (PDAC): This is a cancer that starts in the duc...
Phase 1
Cincinnati, Ohio, United States and 25 other locations
activity of LY3962673 as monotherapy and in combination with other chemotherapy agents in participants with KRAS G12D-mutant advanced solid tumor...
Phase 1
Cincinnati, Ohio, United States and 52 other locations
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