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open label, multi-center, clinical study of Chimeric Antigen Receptor T Cells (CAR-T) targeting claudin18.2 in patients with advanced gastric, pancreatic...
Phase 1, Phase 2
Toronto, Ontario, Canada and 15 other locations
phosphorylase (MTAP)-deleted gastrointestinal, biliary tract, or pancreatic cancers. The study also aims to determine the safety pr...
Phase 1
Toronto, Ontario, Canada and 76 other locations
to participants. Part C will use the information from Parts A and B to see if PF-08046049/SGN-BB228 is safe and if it works to treat solid tumor...
Phase 1
Toronto, Ontario, Canada and 29 other locations
This research is designed to determine if experimental treatment with PARP inhibitor, AZD5305, alone, or in combination with anti-cancer age....
Phase 1, Phase 2
Toronto, Ontario, Canada and 67 other locations
to assess the safety, tolerability, PK, PD, immunogenicity and anti-tumor activity of zenocutuzumab (MCLA-128) in patients with solid tumors...
Phase 2
Toronto, Ontario, Canada and 63 other locations
dose escalation (Phase 1) consists of patients with advanced solid tumors refractory to standard of care, or for whom no standard of care ex...
Phase 1, Phase 2
Toronto, Ontario, Canada and 7 other locations
This phase II trial studies cediranib maleate in combination with olaparib in treating patients with solid tumors that have spread to other ...
Phase 2
Toronto, Ontario, Canada and 15 other locations
BOLD-100 is an intravenously administered sterile solution containing the ruthenium-based small molecule. BOLD-100 has been shown to preferentially d...
Phase 1, Phase 2
Toronto, Ontario, Canada and 13 other locations
of AZD0901 as monotherapy and in combination with anti-cancer agents in participants with locally advanced unresectable or metastatic solid ...
Phase 2
Toronto, Ontario, Canada and 50 other locations
The purpose of this study is to compare overall survival of quemliclustat, nab-paclitaxel and gemcitabine versus placebo, nab-paclitaxel and gemcitab...
Phase 3
Toronto, Canada and 135 other locations
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