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Microbiology of Severe Acute Tonsillitis, Peritonsillar Cellulitis, and Infectious Mononucleosis

T

Tejs Ehlers Klug

Status

Unknown

Conditions

Peritonsillar Cellulitis
Infectious Mononucleosis
Acute Tonsillitis

Treatments

Other: Throat swabbing

Study type

Observational

Funder types

Other

Identifiers

Details and patient eligibility

About

Prospective, observational study of the microbiology of patients referred to a tertiary care center with severe acute tonsillitis, peritonsillar cellulitis, or infectious mononucleosis.

Full description

Patients referred to tertiary care centers with acute throat infections are most often treated with antibiotics. However, very little is know concerning the prevalent pathogens in patients with acute throat infections without abscess formation. Evidence suggests that Fusobacterium necrophorum plays an important role in complications of acute tonsillitis (e.g. peritonsillar abscess), but also uncomplicated acute tonsillitis.

This study aims to explore the throat microbiology of patients with severe acute tonsillitis, peritonsillar cellulitis, or infectious mononucleosis with a special attention to a possible role of Fusobacterium necrophorum.

Enrollment

350 estimated patients

Sex

All

Ages

15 to 40 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  1. Patients referred to our tertiary care center with acute tonsillitis with or without signs of peritonsillar cellulitis and with or without infectious mononucleosis.
  2. Center Score 3 or 4.

Exclusion criteria

  1. Abscess formation.
  2. Previous tonsillectomy.

Trial design

350 participants in 4 patient groups

Acute tonsillitis
Description:
Patients referred to the tertiary care center with severe acute tonsillitis but without peritonsillar cellulitis, infectious mononucleosis, or abscess formation.
Treatment:
Other: Throat swabbing
Peritonsillar cellulitis
Description:
Patients referred to the tertiary care center with severe acute tonsillitis and peritonsillar cellulitis but without abscess formation.
Treatment:
Other: Throat swabbing
Infectious mononucleosis
Description:
Patients referred to the tertiary care center with acute tonsillitis and biochemical or serological signs of infectious mononucleosis but without abscess formation.
Treatment:
Other: Throat swabbing
Controls
Description:
Patients treated for conditions not related to the throat and without signs or symptoms of recent throat disease.
Treatment:
Other: Throat swabbing

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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